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Reversing Endothelial Harm


Age-Associated Harm to Endothelium

The endothelium is the innermost layer of blood vessels, which might develop into broken as we become older, an essential side of heart problems. I found the very important position of the endothelium once I found that I’ve hypertension if it isn’t managed by metoprolol (a medication I’m on to forestall coronary heart arrhythmias, which had been a facet impact of my needing a coronary heart valve alternative). The blood stress incident and what I subsequently discovered from it’s mentioned right here. My most essential takeaway was to ensure I’ve a number of nitrates in my weight loss program, from meals like beets and arugula. That has been working nicely for holding blood stress regular. However that’s serving to to maintain my blood vessels dilating usually, regardless of age-related harm to the endothelium. As I discussed on the finish of that earlier put up, I’d prefer to study cut back harm to the endothelium.

It seems that is potential, and that is mentioned within the newest video on Dr. Greger’s nutritionfacts web site. The secret’s the position of endothelial progenitor cells, which assist with the well being of the endothelium. Within the video an enchanting research is described that demonstrates this. Peripheral artery illness is a sort of heart problems the impacts blood vessels just like the legs, in the same method to how the coronary arteries are broken in coronary artery illness. The blood vessels could be so badly broken that victims are severely restricted in train capability, like solely with the ability to stroll for a minute or much less. As well as, necessity for amputation could be a main consequence of peripheral artery illness. The researchers break up contributors into a bunch that obtained bone marrow transplants, and a management group that obtained solely an injection of their very own blood. The group with bone marrow transplants had considerably improved train time, versus no enchancment within the management. Additionally, within the management group, throughout follow-up over the following months, 14% required amputations over the following months versus none within the handled group. The improved arterial operate within the handled group is expounded to enhanced impact of endothelial progenitor cells [2].

So Dr. Greger now examined how can we increase endothelial progenitor cells by life-style means. Two very important elements are usually not smoking (and avoiding publicity to secondhand smoke), and train. For weight loss program, essential elements are decreasing saturated fats consumption, consuming a whole-food plant-based weight loss program, and particularly consuming berries, onions, and consuming inexperienced tea. I’m already checking all of the containers on this listing besides the final two, so I intend to spice up onion consumption and check out inexperienced tea. The endothelium of my arteries most likely already appears just like the “60+” within the image above. It’s thrilling to assume it’s potential to reverse this and have successfully youthful arteries.


  1. Sharma, S, et al, “Randomized, Double-Blind, Placebo-Managed Trial to Consider Security and Therapeutic Efficacy of Angiogenesis Induced by Intraarterial Autologous Bone Marrow–Derived Stem Cells in Sufferers with Extreme Peripheral Arterial Illness”, Journal of Vascular and Interventional Radiology, 2021. on-line right here
  2. Teraa, M, et al, “Impact of repetitive intra-arterial infusion of bone marrow mononuclear cells in sufferers with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells by way of Transcutaneous Intra-arterial Supplementation”, Circulation, 2015. on-line right here.

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